Investigating the Effects of Kelulut Honey on Letrozole-Induced Polycystic Ovary Syndrome Model In Rats.

Abstract

Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility. It is a combination of reproductive, endocrine, and metabolic diseases. Kelulut honey is stingless bee honey reported in many studies to possess benefits toward the metabolic, endocrine, and reproductive system. The present study investigated the effects of kelulut honey on body weight, estrus cycle regularities, blood glucose level, and ovarian histology analysis in letrozole-induced PCOS in rats. PCOS was induced in Sprague–Dawley rats with 1mg/kg letrozole orally once daily for 21 consecutive days. Kelulut honey (0.5, 1, and 2mg/kg) or distilled water was administered for 35 days after PCOS induction. Treatment with 1 mg/kg Kelulut honey significantly increases the corpus luteum count in the ovary of PCOS-induced rats. However, no significant changes were found in other ovarian histology analyses which are antral follicles, atretic follicles, and cyst count among the different groups. In addition, no changes were recorded in body weight, blood glucose, and estrus cycle regularities among the different groups. In conclusion, kelulut honey showing potential in inducing ovulation assessed through increasing the count of corpus luteum.